Synchronous Ovarian and Endometrial Carcinoma: a Report of Two Cases

We report 2 cases of synchronous ovarian and endometrial tumour presented to us with irregular bleeding per vagina. Case 1: 51 year old, nulliparous lady came with irregular vaginal bleeding with mass per abdomen. Ultrasonogram of pelvis showed bulky heterogeneous uterus with solid and cystic lesions in both adnexa.CA125 was 293 IU/ml. Patient underwent staging laparotomy with radical hysterectomy. Histopathology confirmed simultaneous independent endometrial adenocarcinoma with bilateral ovarian clear cell carcinoma with omental metastasis. Case 2: 46 year old lady with complaints of irregular bleeding per vagina.CA125 was 2859 IU/ml. Computed tomogram of abdomen showed large pelvic lesion with solid and cystic components suggestive of ovarian neoplasm. Patient underwent staging laparotomy with radical hysterectomy. Histopathology revealed endometrioid adenocarcinoma with focal squamous differentiation in uterus and moderately differentiated endometrioid adenocarcinoma of ovary. She received external beam radiotherapy along with carboplatin and paclitaxelbased chemotherapy. Co-existence of primary ovarian and endometrial malignancy though uncommon may present with abnormal uterine bleeding in perimenopausal age group. Hence these women should be evaluated for synchronous tumours for optimal adjuvant treatment and better prognosis. Author Affiliations: 1-3 Dept of Obstetrics & Gynaecology, Kasturba Medical College, Manipal, Karnataka, India – 576104.